A neurologist's personal battle against Alzheimer's disease
Today the FDA granted accelerated approval of the anti-amyloid monoclonal antibody lecanemab, now going by the trade name Leqembi. I have mixed feelings about this. Lecanemab is the only disease-modifying drug so far to...
One Christmas while I was in medical school in Atlanta, Lois and I decided to visit London rather than return to the West Coast to visit our families. It was a memorable week in many...
My friend Ron Louie is a pediatric oncologist and fulltime caregiver for his wife who has Alzheimer’s disease. He blogs regularly, often drawing intriguing comparisons of the search for an effective treatment for Alzheimer’s...
At some point while I was a medical student in the 1970s, I had my cholesterol checked. I think it was part of a pedagogical exercise, and as I recall, only the total cholesterol...
One evening last week, I started coughing a bit. I dismissed it as due to my persistent allergies. A few hours later I felt awful. I had a bad headache, shaking chills, and a temperature...
Last night, my wife Lois and I watched this new documentary film about Greg O’Brien. Although we have never met in person, Greg and I have been email and phone buddies for more than six...
Note: This blog post began life about a year ago as a much shorter post with the same title. A few months later I decided to expand it and submit is as an opinion paper...
In 2015 I volunteered for a longitudinal study of a then new tau-PET scan using the radioactive tracer [18F]-AV1451. It has since been approved for commercial use under the name Flortaucipir. Along with the tau...
Joy Milne is a 72-year-old retired nurse from Perth, Scotland, who has had an extraordinarily sensitive sense of smell, called hyperosmia, all of her life. In some ways it has been a curse. She...
As I have discussed in previous posts, many drugs designed to remove beta-amyloid from the brains of people with Alzheimer’s disease have been designed and tested over the last twenty-plus years. Most of these...
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