A neurologist's personal battle against Alzheimer's disease
After years of failed trials, two and possibly three anti-amyloid monoclonal antibodies have shown efficacy at removing beta-amyloid from the brain of subjects with mild Alzheimer’s disease. Two of them, lecanemab and donanemab, have...
There are now two anti-amyloid monoclonal antibodies that appear to be effective in slowing the progression of cognitive impairment in people with mild Alzheimer’s disease. The benefit may be small, 27% for lecanemab and...
Yesterday Eli Lilly issued a press release summarizing positive results of the TRAILBLAZER-ALZ 2 Phase 3 study showing that donanemab significantly slows cognitive and functional decline in people with early symptomatic Alzheimer’s disease. Donanemab is unique...
Like most people with Alzheimer’s disease, my verbal memory was the first cognitive domain to be affected. Recently it has rapidly been getting worse. On my most recent testing with the Montreal Cognitive Assessment (MoCA),...
Several weeks ago, I signed a contract with the publisher for a collection of essays about Alzheimer’s disease. These are essays I have written over the last several years, and a few days ago I...
Early in my career as a neurologist, probably about 1990, I was asked to consult on a 62-year-old, previously healthy woman who had had a large brain hemorrhage. She had no apparent risk factors...
Today is the release date both in the US and UK for the paperback edition of A Tattoo on my Brain. It is essentially the same as the hardback edition with the addition of a...
My mother was an avid book collector. As a teen, I would browse the book shelves in our home looking for interesting nuggets. One of my favorite finds was The Importance of Living by the Chinese...
Over the last ten years or so, I have noticed increasing trouble understanding what people are saying to me, especially if there are several people speaking at the same time, like at a family...
Early in my career as a general neurologist, there was no way to accurately make a diagnosis of Alzheimer’s disease in a living patient. The only way then to know for sure that a...
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