The alcohol conundrum
There is no disagreement that excessive alcohol consumption is bad for the brain. A 2019 review found that heavy alcohol use in humans was universally associated with an increased risk of all-cause dementia and reduced grey...
Category: New research findings
Tai chi may improve symptoms of mild cognitive impairment in the elderly
Two days ago, Halloween arrived at our house. It has been one of my favorite holidays since my own childhood, but now perhaps even more so, as we share in the excitement and joy...
In my opinion, people with two copies of the APOE-4 allele should not be given anti-amyloid monoclonal antibodies
So far, three anti-amyloid monoclonal antibodies have been approved in the US by the FDA for treatment of dementia or mild cognitive impairment (MCI) caused by Alzheimer’s disease: aducanumab, lecanemab, and most recently donanemab....
Olive oil consumption may reduce risk of dying with dementia
I must admit that when I think of olive oil, I am often reminded first of Popeye’s girlfriend. No, I wasn’t around in 1936, but Olive Oyl and Popeye were still going strong when I...
Brain volume and dementia risk
Although the overall prevalence of dementia has been increasing along with population growth, the incidence of dementia, the number of new cases per year, has actually been decreasing in many parts of the world....
An update on anti-amyloid therapies
My wife and I have just returned from a wonderful visit to Norway. I was quite taken by the legend of the trolls, the mischievous beasts that wreak havoc in the lives of country...
Beach ghosts and donanemab
Yesterday evening as sundown approached, I looked out a window on the west side of our house and saw a startling headless reflection looking back enquiringly at me. The optics were easily explained: I...
CAA and ARIA revisited
Dr. Steven Greenberg is most likely the most knowledgeable expert in the world concerning cerebral amyloid angiopathy (CAA) and the vascular pathology associated with Alzheimer’s disease. Earlier this week, I had the honor of...
Could breaching the blood-brain barrier possibly be useful in treating Alzheimer’s?
Last week in the New England Journal of Medicine, the results of an interesting proof-of-concept study using focused ultrasound to enhance the ability of the anti-amyloid monoclonal antibody aducanumab to cross the blood blood-brain barrier...
Another anti-amyloid monoclonal antibody trial disappoints, but there may still be hope
I last posted on my blog three weeks ago. A few days after that, I came down with what was probably just a bad cold. It was mainly in my chest with a lot of coughing....
Recent Comments