Untangling the words
Several weeks ago, I signed a contract with the publisher for a collection of essays about Alzheimer’s disease. These are essays I have written over the last several years, and a few days ago I...
Author: Dan
Cerebral amyloid angiopathy (CAA) – should it be a contraindication for drugs like lecanemab?
Early in my career as a neurologist, probably about 1990, I was asked to consult on a 62-year-old, previously healthy woman who had had a large brain hemorrhage. She had no apparent risk factors...
Book and film news
Today is the release date both in the US and UK for the paperback edition of A Tattoo on my Brain. It is essentially the same as the hardback edition with the addition of a...
Excessive laxative use and dementia
My mother was an avid book collector. As a teen, I would browse the book shelves in our home looking for interesting nuggets. One of my favorite finds was The Importance of Living by the Chinese...
Hearing loss, aphasia and dementia
Over the last ten years or so, I have noticed increasing trouble understanding what people are saying to me, especially if there are several people speaking at the same time, like at a family...
Biomarkers for Alzheimer’s disease
Early in my career as a general neurologist, there was no way to accurately make a diagnosis of Alzheimer’s disease in a living patient. The only way then to know for sure that a...
A fatal case of multiple brain hemorrhages associated with lecanemab
Today the FDA granted accelerated approval of the anti-amyloid monoclonal antibody lecanemab, now going by the trade name Leqembi. I have mixed feelings about this. Lecanemab is the only disease-modifying drug so far to...
Boxing Day
One Christmas while I was in medical school in Atlanta, Lois and I decided to visit London rather than return to the West Coast to visit our families. It was a memorable week in many...
What about exercise and meditation for elders worried about their cognitive function?
My friend Ron Louie is a pediatric oncologist and fulltime caregiver for his wife who has Alzheimer’s disease. He blogs regularly, often drawing intriguing comparisons of the search for an effective treatment for Alzheimer’s...
Apolipoprotein-4 (APOE-4): bad for the brain and bad for the heart
At some point while I was a medical student in the 1970s, I had my cholesterol checked. I think it was part of a pedagogical exercise, and as I recall, only the total cholesterol...
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