CBS Sunday Morning interview
In a previous post, I mentioned being interviewed for a segment on CBS Sunday Morning. I found out yesterday that the interview will air this Sunday as part of a larger story on the...
Author: Dan
Dog dementia (canine cognitive dysfunction)
Jack, our English cocker spaniel, is seven years old, middle aged for a dog. He may be a little neurotic, after all he is a spaniel, but he is still sharp as a tack and...
Good news and bad news for Aduhelm this week
I was interested to see the report from the Clinical Trials on Alzheimer’s Disease conference held in Boston last week demonstrating a reduction of a blood marker for neurofibrillary tangles in the brain, p-tau...
Crossword controversies
Over and over, perhaps ad nauseum, I have been talking about the evidence-based lifestyle changes that can reduce our risk of getting Alzheimer’s disease and/or slow its progression. These include getting frequent aerobic exercise, eating a...
The role of brain inflammation in Alzheimer’s disease may be more significant in APOE-4 carriers
For over twenty years, there has been growing evidence of the importance of inflammation in Alzheimer’s disease. For a comprehensive review of this topic, follow this link to a 2018 paper in Alzheimer’s & Dementia. Briefly,...
The wreck of the Glenesslin
After finishing my neurology training, I joined a group practice associated with Good Samaritan Hospital in Portland. As part of the décor for my new office, I picked out several old photographs from the...
Tattoo interviews
Beginning in March, over a month before Tattoo was published, I have done twenty-three interviews about the book: ten podcasts, eight radio, three print, one TV, and one webinar. Starting out, I was incredibly stressed about...
The experts weigh in on Aduhelm
In the September 14 issue of the journal Neurology, Alzheimer’s experts have offered their opinions in one editorial and two viewpoint papers, one pro and one against, concerning the FDA approval of aducanumab, now known...
New information on how APOE-4 may increase risk of Alzheimer’s disease
Ever since Dr. Allen Roses and his group at Duke reported in the 1990s that people carrying the APOE-4 gene are at greater risk for getting Alzheimer’s, there has been uncertainty about how a gene that...
Could tau be a successful therapeutic target for Alzheimer’s treatment?
Abnormal tau protein is found in the neurofibrillary tangles found in nerve cells in the brain starting a few years before the onset of cognitive impairment in Alzheimer’s disease. Most drug trials attempting to...
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